溃疡性结肠炎
炎症性肠病
促炎细胞因子
发病机制
医学
愤怒(情绪)
免疫学
炎症
结肠炎
克罗恩病
免疫组织化学
病理
疾病
生物
神经科学
作者
Dirk Foell,Torsten Kucharzik,Matthias Kraft,Thomas Vogl,Clemens Sorg,Wolfram Domschke,Johannes Roth
出处
期刊:Gut
[BMJ]
日期:2003-06-01
卷期号:52 (6): 847-853
被引量:258
摘要
Intestinal inflammation in Crohn's disease (CD) and ulcerative colitis (UC) is characterised by an influx of neutrophils into the intestinal mucosa. S100A12 is a calcium binding protein with proinflammatory properties. It is secreted by activated neutrophils and interacts with the multiligand receptor for advanced glycation end products (RAGE). Promising anti-inflammatory effects of blocking agents for RAGE have been reported in murine models of colitis.To investigate expression and serum concentrations of S100A12 in inflammatory bowel disease (IBD).We performed immunohistochemical studies and immunofluorescence microscopy in biopsies from patients with CD and UC. S100A12 serum concentrations were analysed using a sandwich ELISA.Immunohistochemical studies revealed profound expression of S100A12 in inflamed intestinal tissue from IBD patients whereas no expression was found in tissue from healthy controls. Staining for S100A12 during chronic active CD and UC was restricted to infiltrating neutrophils. Serum S100A12 levels were significantly elevated in patients with active CD (470 (125) ng/ml; p<0.001, n=30) as well as those with active UC (400 (120) ng/ml; p<0.01, n=15) compared with healthy controls (75 (15) ng/ml; n=30). Even in inactive disease, elevated serum concentrations were found, at least in CD. S100A12 levels were well correlated with disease activity in CD and UC.We demonstrated that neutrophil derived S100A12 is strongly upregulated during chronic active IBD, suggesting an important role during the pathogenesis of IBD. Serum S100A12 may serve as a useful marker for disease activity in patients with IBD.
科研通智能强力驱动
Strongly Powered by AbleSci AI