微球
体内
体内分布
材料科学
药物输送
生物医学工程
乳状液
体外
超顺磁性
盐酸盐
磁性纳米粒子
药理学
纳米技术
化学
磁场
医学
纳米颗粒
化学工程
磁化
生物化学
生物技术
生物
量子力学
工程类
物理
作者
Bo Peng,Xinggang Yang,Xin Li,Hao Pan,Zhihong Zhang,Hongfei Liu,MA Shi-lin,Weisan Pan
出处
期刊:Drug Delivery
[Informa]
日期:2010-11-03
卷期号:18 (2): 166-172
被引量:2
标识
DOI:10.3109/10717544.2010.531061
摘要
The objective of this study was to prepare magnetic microspheres as a targeting drug delivery system and to specifically evaluate its targeting efficiency. The magnetic microspheres were prepared by emulsion cross-linking techniques. Targeting efficiency was specifically investigated by experiments of biodistribution on rats and histological study. Adriamycin hydrochloride (ADR)-loaded magnetic microspheres were successfully prepared with the mean diameter of 3.853 μm (± 1.484 μm), and had its speciality of superparamagnetism. The results of the targeting efficiency study showed that application of the external magnetic field significantly increased the ADR concentration from 40.28 μg/ml to 100.70 μg/ml at 10 min, 36.99 μg/ml to 91.16 μg/ml at 60 min, and 13.71 μg/ml to 28.30 μg/ml at 180 min in liver as the targeting tissue. The relative uptake efficiencies in liver by injection treatment of ADR magnetic microspheres with external magnetic field were 3.87, 5.59, and 3.34 at 10 min, 60 min, and 180 min after administration, respectively. In conclusion, distinguished targeting efficiency was displayed, which indicated that the magnetic microspheres could be applied as a novel targeting drug delivery system.
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