沙鼠
胃
幽门螺杆菌
腺癌
癌变
生物
印戒细胞癌
入射(几何)
幽门螺杆菌感染
内科学
接种
胃肠病学
病理
癌症
医学
缺血
物理
光学
作者
Atsushi Sugiyama,Fukuto Maruta,Tatsuo Ikeno,Kimitaka Ishida,Seiji Kawasaki,Tsutomu Katsuyama,Nobuyuki Shimizu,Masae Tatematsu
出处
期刊:Cancer Research
[American Association for Cancer Research]
日期:1998-05-15
卷期号:58 (10): 2067-9
被引量:101
摘要
No previous report has demonstrated the relationship between Helicobacter pylori (HP) infection and gastric carcinogenesis in an experimental animal model. A total of 170 male Mongolian gerbils (MGs) were divided into nine groups (18 < or = n < or = 20 for each group). MGs of four groups were inoculated with HP before or after continuous N-methyl-N-nitrosourea (MNU) administration via the drinking water. Both intestinal-type and diffuse-type adenocarcinomas, including signet ring-cell carcinomas, were found at 40 weeks after the study commenced, but only in the HP inoculation groups with MNU exposure and not in the MNU alone or HP inoculation alone control groups. The present findings demonstrate that HP infection increases the incidence of MNU-induced adenocarcinoma of the glandular stomach in MGs.
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