蜂胶
红色毛癣菌
去甲二氢愈创木酸
传统医学
木脂素
生物
化学
植物
抗真菌
微生物学
医学
生物化学
酶
花生四烯酸
作者
María Belén Agüero,Laura Svetaz,Marianela Sánchez,Lorena Luna,Beatriz Lima,María Liza López,Susana Zacchino,Jorge Alejandro Palermo,Daniel Alberto Wunderlin,Gabriela Egly Feresin,Aníbal Alejandro Tapia
标识
DOI:10.1016/j.fct.2011.05.008
摘要
The chemical profile and botanical origin of Andean Argentinian propolis were studied by HPLC–ESI–MS/MS and GC–MS techniques as well as the antifungal activity according to CLSI protocols. Dermatophytes and yeasts tested were strongly inhibited by propolis extracts (MICs between 31.25 and 125 μg/mL). The main antifungal compounds were: 3′methyl-nordihydroguaiaretic acid (MNDGA) 1, nordihydroguaiaretic acid (NDGA) 2 and a NDGA derivative 3, showing strong activity against Trichophyton mentagrophytes, T. rubrum and Microsporum gypseum (MICs between 15.6 and 31.25 μg/mL). The lignans 1 and 2 showed activities against clinical isolates of Candidas spp., Cryptococcus spp., T. rubrum and T. mentagrophytes (MICs and MFCs between 31.25 and 62.5 μg/mL). The lignan and volatile organic compounds (VOCs) profiles from propolis matched with those of exudates of Larrea nitida providing strong evidences on its botanical origin. These results support that Argentinian Andean propolis are a valuable natural product with potential to improve human health. Six compounds (1–6) were isolated from propolis for the first time, while compounds 1 and 3–6 were reported for first time as constituents of L. nitida Cav.
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