活性氧
再灌注损伤
化学
缺血
药理学
药代动力学
超氧化物
过氧化氢
肝损伤
生物化学
医学
内科学
酶
作者
Hidemasa Katsumi,Kuniaki Fukui,Kanako Sato,Shoko Maruyama,Shugo Yamashita,Erika Mizumoto,Kosuke Kusamori,Munetaka Oyama,Mizuka Sano,Toshiyasu Sakane,Akira Yamamoto
出处
期刊:Metallomics
[Oxford University Press]
日期:2014-01-01
卷期号:6 (5): 1050-1056
被引量:49
摘要
Reactive oxygen species (ROS) are involved in the pathophysiology of ischemia/reperfusion injury. To protect mouse hepatocytes from ischemia/reperfusion injury, we prepared two different sizes of citric acid-protected platinum nanoparticles (Pt-NPs), which exhibited ROS-scavenging activities and selective delivery to a specific type of liver cell. Small Pt-NPs (30 nm) reduced the superoxide anion, hydrogen peroxide, and hydroxyl radical levels in solution to a greater extent than did large Pt-NPs (106 nm). Large and small Pt-NPs predominantly accumulated in hepatic nonparenchymal cells after intravenous injection into mice. In a mouse model of ischemia/reperfusion injury, in which hepatic injury was induced by occluding the portal vein for 15 min followed by 6 h reperfusion, the increase in plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities was inhibited by a bolus intravenous injection of either large or small Pt-NPs. However, small Pt-NPs inhibited the increase in these markers of hepatic injury to a greater extent than did large Pt-NPs. These results indicate that Pt-NPs can be used to prevent hepatic ischemia/reperfusion injury. To our knowledge, this is the first report demonstrating the pharmacokinetics and efficacy of Pt-NPs to prevent hepatic ischemia/reperfusion injury.
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