化学
抗氧化剂
膜
脂质双层
生育酚
维生素E
激进的
双层
生物膜
生物物理学
维生素
脂质体
生物化学
生物
作者
Drew Marquardt,Justin A. Williams,Norbert Kučerka,Jeffrey Atkinson,Stephen R. Wassall,John Katsaras,Thad A. Harroun
摘要
We show evidence of an antioxidant mechanism for vitamin E which correlates strongly with its physical location in a model lipid bilayer. These data address the overlooked problem of the physical distance between the vitamin’s reducing hydrogen and lipid acyl chain radicals. Our combined data from neutron diffraction, NMR, and UV spectroscopy experiments all suggest that reduction of reactive oxygen species and lipid radicals occurs specifically at the membrane’s hydrophobic–hydrophilic interface. The latter is possible when the acyl chain “snorkels” to the interface from the hydrocarbon matrix. Moreover, not all model lipids are equal in this regard, as indicated by the small differences in vitamin’s location. The present result is a clear example of the importance of lipid diversity in controlling the dynamic structural properties of biological membranes. Importantly, our results suggest that measurements of aToc oxidation kinetics, and its products, should be revisited by taking into consideration the physical properties of the membrane in which the vitamin resides.
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