生物
MHC I级
细胞生物学
滋养层
主要组织相容性复合体
获得性免疫系统
MHC限制
免疫学
抗原呈递
背景(考古学)
CD8型
免疫系统
胎盘
蜕膜
豁免特权
T细胞
遗传学
怀孕
胎儿
古生物学
作者
Emma Reeves,Estelle James
出处
期刊:Placenta
[Elsevier]
日期:2017-08-01
卷期号:56: 34-39
被引量:16
标识
DOI:10.1016/j.placenta.2017.02.025
摘要
Classical and non-classical MHC class I (MHC I) molecules displayed at the cell surface are essential for the induction of innate and adaptive immune responses. Classical MHC I present endogenously derived peptides to CD8+ T cells for immunosurveillance of infected or malignant cells. By contrast, non-classical MHC I, in particular HLA-G, also display peptides, but primarily act as immunomodulatory ligands for the innate immune response and are an important component for extravillous trophoblast invasion to form the placenta in pregnancy. Endoplasmic Reticulum AminoPeptidase 1 (ERAP1), which trims peptides in the ER to generate ligands for MHC I loading, is a key regulator of the peptide repertoire and has a significant impact on the formation of stable MHC I at the cell surface. ERAP1 also plays a role in angiogenesis, cell cycle progression and migration, events that are shared between tumour cells and placenta formation. Here we discuss the similarities between tumour and extravillous trophoblast cells in their immune modulatory, invasion, migration and proliferation properties in the context of ERAP1 and its role in establishment of solid tumours and placenta formation.
科研通智能强力驱动
Strongly Powered by AbleSci AI