Nanocrystals of Glycyrrhetinic Acid: Comparative Efficiency of Particle Size Reduction Techniques

Background and Objective: Glycyrrhetinic acid (GHA) potential has therapeutic and nutricosmetic activity. Poor aqueous solubility is the main limiting factor in usage of GHA in variety of application. The main objective of this study is to improve aqueous solubility of GHA by using various nanonization techniques. Keywords: Glycyrrhetinic acid, glycyrrhizic acid, nanocrystals, production methods, high pressure homogenization, bead milling, combination technology, smartCrystal®