A B S T R A C T Background: Hypertension in patients with renal failure is very common and is one of the most important factors involved in creation and progression of cardiovascular disease in dialysis patients. Also increase blood volume is the most important factor in blood pressure in these patients. Objective: This was a descriptive cross-sectional study and 30 dialysis patients undergoing hemodialysis in Darab Imam Hassan Mojtaba hospital in Iran were selected. Systolic and diastolic blood pressure, mean arterial pressure and weight changes were measured before and after dialysis during four consecutive hemodialysis. Data were analyzed by paired t-test. Results: Mean age of samples was 53.23 ± 2.87. Prevalence of hypertension was high, but there was no significant relationship between age, sex, duration of dialysis with blood pressure. Also there was no significant correlation between weight changes and blood pressure. The results showed that weight changes had no significant effect on blood pressure. Conclusion: This finding may indicate that other factors except blood volume were affected on variation of blood pressure.