普拉克索
杂质
光延反应
化学
组合化学
色谱法
立体化学
有机化学
医学
病理
疾病
帕金森病
作者
Tianwen Hu,Feipu Yang,Tao Jiang,Weiming Chen,Jian Zhang,Jianfeng Li,Xiangrui Jiang,Jingshan Shen
标识
DOI:10.1021/acs.oprd.6b00182
摘要
Three impurities of pramipexole dihydrochloride were synthesized, and the possible generation mechanisms and the preparation methods of some impurities were reviewed. The desired configuration at C7 of 3 was built by a Mitsunobu reaction.
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