溶血磷脂酸
1-磷酸鞘氨醇
生物
串扰
脂质信号
血管生成
炎症
纤维化
神经科学
细胞信号
细胞生物学
受体
信号转导
癌症研究
免疫学
鞘氨醇
医学
病理
生物化学
物理
光学
作者
Kuniyuki Kano,Junken Aoki,Timothy Hla
出处
期刊:Annual Review of Pathology-mechanisms of Disease
[Annual Reviews]
日期:2022-01-24
卷期号:17 (1): 459-483
被引量:40
标识
DOI:10.1146/annurev-pathol-050420-025929
摘要
Lysophospholipids, exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are produced by the metabolism and perturbation of biological membranes. Both molecules are established extracellular lipid mediators that signal via specific G protein–coupled receptors in vertebrates. This widespread signaling axis regulates the development, physiological functions, and pathological processes of all organ systems. Indeed, recent research into LPA and S1P has revealed their important roles in cellular stress signaling, inflammation, resolution, and host defense responses. In this review, we focus on how LPA regulates fibrosis, neuropathic pain, abnormal angiogenesis, endometriosis, and disorders of neuroectodermal development such as hydrocephalus and alopecia. In addition, we discuss how S1P controls collective behavior, apoptotic cell clearance, and immunosurveillance of cancers. Advances in lysophospholipid research have led to new therapeutics in autoimmune diseases, with many more in earlier stages of development for a wide variety of diseases, such as fibrotic disorders, vascular diseases, and cancer.
科研通智能强力驱动
Strongly Powered by AbleSci AI