聚乳酸
材料科学
复合材料
钛酸钡
复合数
纺纱
接触角
聚合物
陶瓷
作者
Francesco Boschetto,Hoan Ngoc Doan,Phu Phong Vo,Matteo Zanocco,Kenta Yamamoto,Wenliang Zhu,Tetsuya Adachi,Kenji Kinashi,Elia Marin,Giuseppe Pezzotti
出处
期刊:Molecules
[MDPI AG]
日期:2021-05-14
卷期号:26 (10): 2918-2918
被引量:16
标识
DOI:10.3390/molecules26102918
摘要
The present work investigated the effect of Polylactic acid (PLA) fibers produced by centrifugal spinning with incorporated BaTiO3 particles to improve their bacteriostatic behavior. The PLA matrix and three composites, presenting three different amounts of fillers, were subjected to UV/O3 treatment monitoring the possible modifications that occurred over time. The morphological and physical properties of the surfaces were characterized by different microscopic techniques, contact angle, and surface potential measurements. Subsequently, the samples were tested in vitro with human dermal fibroblasts (HDF) to verify the cytotoxicity of the substrates. No significant differences between the PLA matrix and composites emerged; the high hydrophobicity of the fibers, derived by the polymer structure, represented an obstacle limiting the fibroblast attachment. Samples underwent bacterial exposure (Staphylococcus epidermidis) for 12 and 24 h. Increasing the concentration of BT, the number of living bacteria and their distribution decreased in comparison with the PLA matrix suggesting an effect of the inorganic filler, which generates a neutralization effect leading to reactive oxygen species (ROS) generation and subsequently to bacterial damages. These results suggest that the barium titanate (BT) fillers clearly improve the antibacterial properties of PLA fibers after aging tests made before bacterial exposure, representing a potential candidate in the creation of composites for medical applications.
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