Pattern and impact of drug-induced liver injury in South African patients with Stevens-Johnson syndrome/toxic epidermal necrolysis and a high burden of HIV

Epidermal necrolysis (EN), a severe cutaneous adverse drug reaction characterized by epidermal detachment, encompasses Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN). Stevens-Johnson syndrome affects 10% or less of the body surface area, and there is TEN of 30% or greater with SJS/TEN overlap in between. Epidermal necrolysis is a delayed T cell–mediated hypersensitivity reaction in which mortality reaches 40%, depending on variables in the prognostic Severity-of-Illness Score for Toxic Epidermal Necrolysis tool.