非酒精性脂肪肝
胰岛素抵抗
肝硬化
脂肪肝
内科学
脂联素
2型糖尿病
脂肪性肝炎
糖尿病
发病机制
胃肠病学
医学
肝细胞癌
生物信息学
慢性肝病
内分泌学
疾病
生物
标识
DOI:10.1007/978-981-15-7360-6_20
摘要
Nonalcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases worldwide and has garnered increasing attention in recent decades. NAFLD is characterized by a wide range of liver changes, from simple steatosis to nonalcoholic steatohepatitis (NASH), cirrhosis, and hepatocellular carcinoma. The pathogenesis of NAFLD/NASH is very complicated and involves lipid accumulation, insulin resistance, inflammation, and fibrogenesis. In addition, NAFLD is closely associated with complications such as obesity, dyslipidemia, and type 2 diabetes. In particular, the clinical spectrum, pathophysiology, and therapeutic options of NAFLD share many things in common with diabetes. Insulin resistance is an underlying basis for the pathogenesis of diabetes and NAFLD. This chapter focuses on the molecular mechanism involved in the pathogenesis of insulin resistance, diabetes, and NASH/NAFLD including those that drive disease progression such as oxidative stress, genetic and epigenetic mechanisms, adiponectin, cytokines, and immune cells.
科研通智能强力驱动
Strongly Powered by AbleSci AI