An approach for the rapid synthesis of moderately sized dendritic macromolecules

A general method for the synthesis of a dendrimeric series with homologous terminal groups is described. FABMS measurements confirm the molecular mass of the reported dendrimers. The result of size exclusion chromatographic (SEC) analysis correlates well with the relative molecular mass (RMM) of the early members of the series. However, deviations in measurements of molecular mass by SEC and FABMS begin to appear for larger members of the series, suggesting a more spherical conformation when the terminal group exceeds propyl.