医学
膀胱过度活动
雌激素
雌激素疗法
泌尿系统
下尿路症状
妇科
泌尿科
更年期
激素疗法
激素替代疗法(女性对男性)
重症监护医学
内科学
前列腺
替代医学
病理
乳腺癌
癌症
睾酮(贴片)
作者
Dudley Robinson,Linda Cardozo,Ian Milsom,Montserrat Espuña Pons,Michael Kirby,Heinz Koelbl,Mark E. Vierhout
摘要
Estrogens are known to have a major role in the function of the lower urinary tract although the role of exogenous estrogen replacement therapy in the management of women with lower urinary tract dysfunction remains controversial. Whilst for many years systemic and vaginal estrogen therapy was felt to be beneficial in the treatment of lower urinary and genital tract symptoms this evidence has recently been challenged by large epidemiological studies investigating the use of systemic hormone replacement therapy. Consequently the role of estrogen in the management of postmenopausal women with Overactive Bladder (OAB) remains uncertain. In addition the evidence base regarding the use of exogenous estrogen therapy has changed significantly over the last decade and has led to a major changes in current clinical practice. The aim of this article is to review the evidence for the role of estrogen therapy in the management of OAB focusing on current knowledge with regard to both systemic and local estrogen therapy as well as investigating the emerging role of combination therapy with antimuscarinic agents.
科研通智能强力驱动
Strongly Powered by AbleSci AI