Cryo-EM structure of human GPR158 receptor coupled to the RGS7-Gβ5 signaling complex
作者
Dipak N. Patil,Shikha Singh,Thibaut Laboute,Timothy S. Strutzenberg,Xingyu Qiu,Di Wu,Scott J. Novick,Carol V. Robinson,Patrick R. Griffin,John F. Hunt,Tina Izard,Appu K. Singh,Kirill A. Martemyanov
出处
期刊:Science [American Association for the Advancement of Science (AAAS)] 日期:2021-11-18
GPR158 is an orphan G-protein-coupled receptor (GPCR) highly expressed in the brain where it controls synapse formation and function. GPR158 has also been implicated in depression, carcinogenesis a...