神经炎症
自闭症
自闭症谱系障碍
医学
促炎细胞因子
中枢神经系统
神经科学
免疫系统
炎症
心理学
生物信息学
精神科
免疫学
生物
作者
Chrystiane Vasconcelos Andrade Toscano,Leonardo Barros,Ahlan Benezar Lima,Thiago Nunes,Humberto M. Carvalho,Joana M. Gaspar
标识
DOI:10.1016/j.neubiorev.2021.07.023
摘要
The worldwide prevalence of ASD is around 1%. Although the pathogenesis of ASD is not entirely understood, it is recognized that a combination of genetic, epigenetics, environmental factors and immune system dysfunction can play an essential role in its development. It has been suggested that autism results from the central nervous system derangements due to low-grade chronic inflammatory reactions associated with the immune system activation. ASD individuals have increased microglial activation, density, and increased proinflammatory cytokines in the several brain regions. Autism has no available pharmacological treatments, however there are pedagogical and psychotherapeutic therapies, and pharmacological treatment, that help to control behavioral symptoms. Recent data indicate that exercise intervention programs may improve cognitive and behavioral symptoms in children with ASD. Exercise can also modify inflammatory profiles that will ameliorate associated metabolic disorders. This review highlights the involvement of neuroinflammation in ASD and the beneficial effects of physical exercise on managing ASD symptoms and associated comorbidities.
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