化学
电化学
氢键
阴极保护
级联
金属
无机化学
分子间力
分子
有机化学
电极
物理化学
色谱法
作者
Zirong Zou,Genuo Cai,Weihao Chen,Canlin Zou,Yamei Li,Hongting Wu,Lu Chen,Jinhui Hu,Yibiao Li,Yubing Huang
标识
DOI:10.1021/acs.joc.1c01845
摘要
An electrochemical protocol for the construction of substituted isoindolinones via reduction/amidation of 2-carboxybenzaldehydes and amines has been realized. Under metal-free and external-reductant-free electrolytic conditions, the reaction achieves the cascade formation of intermolecular C-N bonds and provides a series of isoindolinones in moderate to good yields. The deuterium-labeling experiment proves that the hydrogen in the methylene of the product is mainly provided by H2O in the system.
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