Pressure or force sensors that can reliably detect a broad range of pressure with high sensitivity are prerequisite for applications such as human-machine interface, electronic skin in robotics, and health monitoring. This paper presents a novel approach to fabricate a highly sensitive capacitive pressure sensor by introducing a zinc oxide nanowire (ZnO NW) interlayers between the polydimethylsiloxane (PDMS)/electrodes interface in the conventional metal-insulator-metal architecture. The sensing performances of PDMS-based pressure sensors with and without ZnO NW interlayers were investigated. The ZnO NW interlayers reinforced the electrical connection from metal to PDMS to significantly enhance the device performance with ~50 times improvement in sensitivity (from 0.125 %kPa-1to 5.6452 %kPa-1at a low-pressure range (0-10 kPa)) with respect to conventional PDMS only dielectric-based capacitive sensors.