电子传输链
电子受体
二氢月桂酸脱氢酶
琥珀酸脱氢酶
氧气
电子流
电子
生物物理学
呼吸链
化学
线粒体呼吸链
线粒体
NADH脱氢酶
光化学
生物化学
生物
酶
线粒体DNA
物理
有机化学
光合作用
基因
量子力学
作者
Jessica B. Spinelli,Paul Rosen,Hans‐Georg Sprenger,Anna M. Puszynska,Jessica L. Mann,Julian M. Roessler,Andrew L. Cangelosi,Antonia Henne,Kendall J. Condon,Tong Zhang,Tenzin Kunchok,Caroline A. Lewis,Navdeep S. Chandel,David M. Sabatini
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2021-12-03
卷期号:374 (6572): 1227-1237
被引量:83
标识
DOI:10.1126/science.abi7495
摘要
For electrons to continuously enter and flow through the mitochondrial electron transport chain (ETC), they must ultimately land on a terminal electron acceptor (TEA), which is known to be oxygen in mammals. Paradoxically, we find that complex I and dihydroorotate dehydrogenase (DHODH) can still deposit electrons into the ETC when oxygen reduction is impeded. Cells lacking oxygen reduction accumulate ubiquinol, driving the succinate dehydrogenase (SDH) complex in reverse to enable electron deposition onto fumarate. Upon inhibition of oxygen reduction, fumarate reduction sustains DHODH and complex I activities. Mouse tissues display varying capacities to use fumarate as a TEA, most of which net reverse the SDH complex under hypoxia. Thus, we delineate a circuit of electron flow in the mammalian ETC that maintains mitochondrial functions under oxygen limitation.
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