三苯胺
材料科学
纳米技术
分子成像
分子工程
制作
纳米颗粒
分子
组合化学
化学
光电子学
有机化学
体内
病理
生物技术
生物
医学
替代医学
作者
Zeng‐Ming Yang,Zhijun Zhang,Ziqiang Lei,Dong Wang,Hengchang Ma,Ben Zhong Tang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2021-04-02
卷期号:15 (4): 7328-7339
被引量:82
标识
DOI:10.1021/acsnano.1c00585
摘要
Precise molecular engineering is the most fundamental and even a great challenging task for the development of small organic fluorophores used as phototheranostic agents in multimodal imaging-guided synergistic therapy. To the best of our knowledge, there have been no previous reports regarding the fine fabrication of molecular structure from a proof-of-concept study, providing a single molecule with all phototheranostic modalities. Herein, an electron donating–accepting (D–A) system is constructed by using triphenylamine derivatives as donors and diverse electron-deficient partners as acceptors, yielding aggregation-induced emission luminogens with tunable emission wavelength (up to 933 nm) and light absorption capability (ε up to 6.9 × 104 M–1 cm–1). Notably, by integrating the spin–orbit coupling-promoted carbonyl group and the strong stretching vibrations of −CN to the D–A systems, a highly performing phototheranostic agent, namely, MeTIC, is constructed. When encapsulating MeTIC into nanovehicles, the obtained MeTIC nanoparticles show excellent performance in multimodality theranostics for cancer treatment. This work is expected to provide an organic phototheranostic agent designing principle for potential clinical trials.
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