The proceeding of coevolution of mammalian herbivores and plant mediated by plant secondary compounds was reviewed, based on the modes of coevoluiton of animal-plant. Coevolution is viewed as “evolution of a trait of one species in response to a trait of another species, which trait itself has evolved in response to a trait in the first species”. The modes of coevolution of animal-plant includes pairwise coevolution, diffuse coevolution, escape-radical coevolution, diversifying coevolution, parallel cladogensis (cospeciation), reciprocal evolution et al. Pairewise coevolution requires that the participants exhibit evolutionary interactions over long periods of time. Diffuse coevolution and herbivore adaptation to plant metabolites may occur over long or relatively short periods depending on the intensity of interaction. Coevolution may or may not involve cospeciation. Possibly the only consistent aspect of definitions for evolution is the requirement for some form of reciprocity of evolutionary change.