沸石咪唑盐骨架
咪唑酯
Zeta电位
肺癌
二甲双胍
细胞毒性
粒径
A549电池
核化学
材料科学
体外
生物物理学
医学
化学
纳米颗粒
纳米技术
内科学
金属有机骨架
生物化学
吸附
无机化学
有机化学
物理化学
生物
胰岛素
作者
Vaidevi Sethuraman,Narra Kishore,Azeera Mohamed Saliq,Loganathan Gayathri,Ruckmani Kandasamy
标识
DOI:10.1080/10667857.2021.1905207
摘要
A simple and cost-effective synthesis method for zeolitic imidazolate framework-8 (ZIF-8) was developed and loaded with metformin (MET@ZIF-8) for pH sensitive-release behaviour for the treatment of lung cancer. ZIF-8 and MET@ZIF-8 were subjected to particle size, zeta potential analysis and HR-TEM through which it shows evidence that the particles had spherical morphology and nanosize. Percentage of metformin (MET) loading in the ZIF-8 was found to be 63.39 ± 1.32%. Dissociation of ZIF-8 into its coordination ions at acidic conditions (pH 5–6) thereby leads to the release of MET at a higher drug release rate (98%) compared to physiological conditions (pH 7.4) the drug release rate at 35%. Pore volume and pore size of ZIF-8 (1242 m2/g) gets reduced to 1042.00 m2/g after incorporation of MET in ZIF-8. In-vitro cytotoxicity assay results showed the enhanced cytotoxicity for MET @ZIF-8 compared to free MET in a dose dependent manner in human lung adenocarcinoma cells A549.
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