前药
纳米医学
体内分布
体内
药品
材料科学
药物输送
纳米技术
生物医学工程
体外
药理学
化学
纳米颗粒
医学
生物化学
生物技术
生物
作者
Tao Sun,Guangping Zhang,Qingbing Wang,Qinjun Chen,Han Y. H. Chen,Yifei Lü,Lisha Li,Yu Zhang,Xi He,Chunhui Ruan,Yujie Zhang,Qin Guo,Chen Jiang
出处
期刊:Biomaterials
[Elsevier]
日期:2018-11-01
卷期号:183: 268-279
被引量:27
标识
DOI:10.1016/j.biomaterials.2018.04.016
摘要
Real-time monitoring drug-release is often regarded crucial in theranostics nanomedicine design, since it provides precise establishment of spatio-temporal activation of the drug-release in vitro and in vivo. A symmetrical self-immolative drug-dye conjugation (DDC) prodrug is developed in this study with disulfide bond as the trigger. The prodrug can be escorted by targeting PEG-PLGA micelles and hereby accumulated in the tumor by both active and passive targeting effect. Glutathione (GSH) with higher concentration in the tumor microenvironment can readily cleave the disulfide bond to initiate a subsequent decomposition of DDC, where the drug and dye can be released simultaneously in a strict one-to-one mode. Upon the disintegration, the “Turned-On” probe can emit near-infrared (NIR) fluorescence, with the aim of providing accurate and real-time information for the prodrugs' activation and biodistribution in vivo in a non-invasive way. Furthermore, the released dye can meanwhile act as a photothermic sensitizer, which can in-situ assist a deep penetration for the released drug in the tumor tissue with enhanced therapeutic efficiency. This “babysitting” strategy provides new reference for designing versatile theranostic nanomedicines for preclinical evaluations and an alternative approach for hyperthermia perfusion in clinic.
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