糖基化
化学
类固醇
糖基转移酶
糖苷
立体化学
生物化学
酶
激素
作者
Chao Wen,Wei Huang,Xue-Lin Zhu,Xiao-San Li,Fan Zhang,Ren‐Wang Jiang
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-01-24
卷期号:20 (3): 534-537
被引量:34
标识
DOI:10.1021/acs.orglett.7b03619
摘要
A permissive steroid glycosyltransferase (UGT74AN1) from Asclepias curassavica exhibited robust capabilities for the regiospecific C3 glycosylation of cardiotonic steroids and C21 steroid precursors, and unprecedented promiscuity toward 53 structurally diverse natural and unnatural compounds to form O-, N-, and S-glycosides, along with the catalytic reversibility for a one-pot transglycosylation reaction. These findings highlight UGT74AN1 as the first regiospecific catalyst for cardiotonic steroid C3 glycosylation and exhibit significant potential for glycosylation of diverse bioactive molecules in drug discovery.
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