植物雌激素
交易激励
雌激素受体
雌激素
兴奋剂
化学
芹菜素
异黄酮素
受体
体外
药理学
报告基因
内生
内分泌学
内科学
雌激素受体
雌激素受体α
生物
生物化学
基因表达
癌症
医学
基因
乳腺癌
抗氧化剂
类黄酮
作者
Dahae Lee,Yujung Jung,Ji Yun Baek,Myoung‐Sook Shin,Sang‐Hyun Lee,Dae‐Hyun Hahm,Sang Cheon Lee,Jae Suk Shim,Su Nam Kim,Ki Sung Kang
摘要
Phytoestrogens are naturally occurring plant‐derived chemicals that exert female hormone‐like activities similar to those of endogenous estrogens. The purpose of this study was to quantitate the estrogenic activity of six chemical constituents (apigenin, hispidulin, cirsimaritin, cirsimarin, pectolinarin, and linarin) of Cirsium japonicum var. maackii using several in vitro assays. Reporter gene activation by each compound was examined using a human breast cancer (MCF‐7) cell‐based transactivation assay. Proliferative activity was also examined using MCF‐7 cells. Reporter gene activation in MCF‐7 cells by cirsimaritin was significantly suppressed by co‐administration of the estrogen receptor (ER) antagonist ICI 182,780, indicating that cirsimaritin is an ER agonist. Under experimental conditions simulating postmenopausal syndrome ( i.e ., a low concentration of estrogen), cirsimaritin exerted beneficial effects on MCF‐7 cells by increasing estrogenic activity. These results suggest that cirsimaritin is an effective estrogenic compound that can improve postmenopausal symptoms.
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