化学
催化作用
烷基化
烯烃
药物化学
螯合作用
立体化学
有机化学
作者
Rajib Mandal,Balakumar Emayavaramban,Basker Sundararaju
出处
期刊:Organic Letters
[American Chemical Society]
日期:2018-05-08
卷期号:20 (10): 2835-2838
被引量:84
标识
DOI:10.1021/acs.orglett.8b00761
摘要
A novel protocol for ortho-C-H alkylation of aromatic and heteroaromatic ketones and esters under Cp*Co(III) catalysis has been developed for the first time. The reaction proceeds through initial cyclometalation via weak chelation-assisted C-H bond activation, followed by coordination of activated alkene, insertion between Co-C, and protodemetalation.
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