Two stereocentered HKR of anti-β,β′-diphenylpropanoxirane and anti-3-phenylethyloxiranes catalysed by Co(iii)(salen)-OAc complex: enantioselective synthesis of (+)-sertraline and (+)-naproxen

Two stereocentered HKR of anti-β,β′-diphenylmethyloxirane and anti-3-phenylethyloxiranes gives enantiopure anti-1,2-diols and oxiranes. This method is utilised for the synthesis of (+)-sertraline and (+)-naproxen.