Application of Lipophilic Balance Modification in the Creation of Potent Synthetic Anionophores

Objective: Synthetic anionophores are created to mediate the transmembrane transport of anions across phospholipid bilayer membranes. By replacing the defective natural anion channels, they are thought to have high potentials as chemotherapeutic agents for the treatment of channelopathies. Keywords: Anion transport activity, anion transporter, channelopathies, ion selectivity, lipophilic balance, lipophilicity.