抗体依赖性细胞介导的细胞毒性
细胞毒性
细胞毒性T细胞
单克隆抗体
免疫疗法
细胞溶解
癌症免疫疗法
抗体
自然杀伤细胞
免疫学
化学
癌症研究
免疫系统
生物
体外
生物化学
作者
Loïs Coënon,Vicente Martín
标识
DOI:10.3389/fimmu.2022.913215
摘要
Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and increasing its efficacy would improve cancer immunotherapy. CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. The knowledge of the mechanism of action of CD16a gave rise to several strategies to improve ADCC, by working on either the mAbs or the NK cell. In this review, we give an overview of CD16a biology and describe the latest strategies employed to improve antibody-dependent NK cell cytotoxicity.
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