Influence of Tumor-Draining Lymph Nodes on Immunotherapy: Lymphadenectomy May Have Its Limits

In this issue of CCR Translations, it is explored whether removing fewer than usual tumor-draining lymph nodes (LN) at surgical resection might offer better outcomes in patients subsequently receiving immunotherapy. These LNs likely host coordinated adaptive immune responses and may be a key reason why neoadjuvant immunotherapy is exhibiting remarkable clinical success. See related article by Long et al., p. 2467.