Injectable crosslinked recombinant collagen nanofiber implants enable robust regenerative repair of photoaged skin

, all THPC-crosslinked SARCI formulations significantly promoted fibroblast migration, proliferation, and differentiation. In a UV-induced photoaging mouse model, THPC-crosslinked SARCI demonstrated excellent biocompatibility and effectively restored epidermal structure, increased dermal density, improved barrier integrity, and promoted robust collagen regeneration. Transcriptomic analysis further suggested that THPC-crosslinked SARCI mitigates UV-induced ECM degradation by modulating MAPK signaling and maintaining tissue homeostasis. Collectively, these findings establish THPC-crosslinked SARCI as a structurally robust, highly biocompatible, and functionally stable recombinant collagen implant with strong translational potential for the treatment of photoaged skin.