Multifaceted anti-bacterial effects of Pistacia chinensis extract against Methicillin-Resistant Staphylococcus aureus through Membrane Disruption, ROS Reduction, and β-Lactamase Inhibition

PciE exhibits potent antibacterial activity against MRSA by targeting membrane integrity, reducing oxidative stress, and interfering with resistance mechanisms. Its combination with methicillin enhances efficacy, offering a promising strategy for combating antibiotic-resistant MRSA infections. While these MIC values are relatively high, the extract's synergistic effect with methicillin and low resistance induction suggest potential topical or adjuvant applications.