模块化设计
微流控
流体学
计算机科学
灵活性(工程)
背景(考古学)
纳米技术
嵌入式系统
瓦片
计算机体系结构
工程类
材料科学
生物
航空航天工程
古生物学
复合材料
操作系统
统计
数学
作者
Louis Jun Ye Ong,Terry Ching,Lor Huai Chong,Seep Arora,Huan Li,Michinao Hashimoto,Ramanuj DasGupta,Po Ki Yuen,Yi‐Chin Toh
出处
期刊:Lab on a Chip
[The Royal Society of Chemistry]
日期:2019-01-01
卷期号:19 (13): 2178-2191
被引量:62
摘要
Multi-organ perfusion systems offer the unique opportunity to mimic different physiological systemic interactions. However, existing multi-organ culture platforms have limited flexibility in specifying the culture conditions, device architectures, and fluidic connectivity simultaneously. Here, we report a modular microfluidic platform that addresses this limitation by enabling easy conversion of existing microfluidic devices into tissue and fluid control modules with self-aligning magnetic interconnects. This enables a 'stick-n-play' approach to assemble planar perfusion circuits that are amenable to both bioimaging-based and analytical measurements. A myriad of tissue culture and flow control TILE modules were successfully constructed with backward compatibility. Finally, we demonstrate applications in constructing recirculating multi-organ systems to emulate liver-mediated bioactivation of nutraceuticals and prodrugs to modulate their therapeutic efficacies in the context of atherosclerosis and cancer. This platform greatly facilitates the integration of existing organs-on-chip models to provide an intuitive and flexible way for users to configure different multi-organ perfusion systems.
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