医学
前列腺癌
雄激素剥夺疗法
安慰剂
恩扎鲁胺
雄激素受体
抗雄激素
内科学
雄激素
肿瘤科
泌尿科
癌症
阉割
病理
激素
替代医学
作者
Kim N.,Neeraj Agarwal,Anders Bjartell,Byung Ha Chung,Andrea Juliana Pereira de Santana Gomes,Robert Given,Álvaro Juárez Soto,Axel S. Merseburger,Mustafa Özgüroĝlu,Hirotsugu Uemura,Dingwei Ye,Kris Deprince,Vahid Naini,Jinhui Li,Shinta Cheng,Margaret K. Yu,Ke Zhang,Julie S. Larsen,Sharon McCarthy,Simon Chowdhury
标识
DOI：10.1056/nejmoa1903307
摘要
Apalutamide is an inhibitor of the ligand-binding domain of the androgen receptor. Whether the addition of apalutamide to androgen-deprivation therapy (ADT) would prolong radiographic progression–free survival and overall survival as compared with placebo plus ADT among patients with metastatic, castration-sensitive prostate cancer has not been determined.
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