DNA
纳米医学
纳米颗粒
化学
生物物理学
纳米生物技术
日冕(行星地质学)
化学工程
纳米技术
材料科学
生物化学
生物
天体生物学
工程类
维纳斯
作者
Darbi Griffith,Dhanya T. Jayaram,Diane M Spencer,David S. Pisetsky,Christine K. Payne
出处
期刊:Biointerphases
[American Institute of Physics]
日期:2020-09-01
卷期号:15 (5)
被引量:25
摘要
There has been much recent interest in the protein “corona,” the nonspecific adsorption of proteins on the surface of nanoparticles used in biological applications. This research investigates an analogous DNA corona. We find that particles (200 nm and 1 μm) incubated with DNA form a DNA corona, with a higher concentration of DNA adsorbed on the surface of cationic nanoparticles. With protein present, a combined DNA and protein corona is formed although DNA in solution displaces protein from the nanoparticle surface. Displacement of protein from the nanoparticle surface is dependent on the concentration of DNA in solution and was also observed for planar surfaces. Overall, we expect this investigation of the DNA corona to be important for nanomedicine applications, as well as disease states, especially systemic lupus erythematosus, in which biological particles with bound DNA are important mediators of inflammation and thrombosis.
科研通智能强力驱动
Strongly Powered by AbleSci AI