海马体
扁桃形结构
创伤性脑损伤
促炎细胞因子
慢性应激
神经退行性变
海马结构
作者
Shingo Enomoto,Takahiro A. Kato
标识
DOI:10.1016/j.neuint.2020.104921
摘要
Microglia, immune cells in the brain, play a crucial role in brain inflammation and synaptic plasticity by releasing inflammatory mediators and neurotrophic factors as well as, phagocytosing synaptic elements. Recent studies have shown peripheral inflammation, immune alteration in the brain are associated with post-traumatic stress disorder (PTSD) in humans. Several preclinical studies using Pavlovian fear conditioning have suggested that microglia are involved in fear memory dysregulation and altered fear neuronal networks. Microglial priming resulting from previous stressful experiences may also have an effect. This review will introduce the current knowledge of microglial contribution to disturbed fear memory regulation, a fundamental feature of PTSD.
科研通智能强力驱动
Strongly Powered by AbleSci AI