Beneficial Effects Induced by TRPM8 Channels Activation to Treat Myocardial Infarction

Undoubtedly, cardiovascular diseases are and will continue to be one of the major health problems of modern society. In fact, despite the adoption of the best available strategies for restoration of the infarct-related artery patency, almost 30% of patients with ST segment elevated MI still develop left ventricular dysfunction and remodeling. nterestingly, transient receptor potential (TRP) channels are involved in various pathological mechanisms in the heart, including arrhythmias, ischemia-reperfusion injuries, Ca 2+handling defects, fibrosis, inherited cardiopathies, as well as demonstrating involvement in different stages of the cardiac remodeling process postinjury. Importantly and extremely relevant, new biological targets are being investigated, that mitigate cardiac remodeling following MI.