重症肌无力
医学
上睑下垂
复视
眼外肌
眼肌无力
弱点
神经肌肉接头
皮肤病科
眼科
外科
神经科学
内科学
生物
作者
Méabh O’Hare,Christopher Doughty
出处
期刊:Seminars in Neurology
[Georg Thieme Verlag KG]
日期:2019-12-01
卷期号:39 (06): 749-760
被引量:15
标识
DOI:10.1055/s-0039-1700527
摘要
Abstract Myasthenia gravis is an antibody-mediated autoimmune disorder of the post-synaptic neuromuscular junction resulting in fluctuating, fatigable weakness. Most patients first present with extraocular symptoms (diplopia and/or ptosis), and in 15% of cases symptoms will remain restricted to only the extraocular muscles (ocular myasthenia gravis [OMG]). The history and clinical examination are of the utmost importance in correctly identifying OMG patients, as supportive serologic or electrodiagnostic studies are frequently nondiagnostic. In this review, we outline a diagnostic approach to OMG (focusing on key clinical features), discuss therapeutic options, and highlight recent developments in the understanding of OMG.
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