生物
ATP结合盒运输机
流出
运输机
计算生物学
多重耐药
超家族
癌症
疾病
药物基因组学
医学
药物发现
溶质载体族
药理学
抗药性
遗传学
生物信息学
基因
病理
作者
Pérez-De Marcos Juan-Carlos,Pérez-Pineda Perla-Lidia,Méndez-Morales Stephanie-Talia,Arellano-Mendoza Mónica-Griselda,Luz María Torres-Espíndola
标识
DOI:10.1007/s11033-021-06155-w
摘要
The ATP binding-cassette superfamily corresponds the mostly transmembrane transporters family found in humans. These proteins actively transport endogenous and exogenous substrates through biological membranes in body tissues, so they have an important role in the regulation of many physiological functions necessary for human homeostasis, as well as in response regulation to several pharmacological substrates. The development of multidrug resistance has become one of the main troubles in conventional chemotherapy in different illnesses including cancer, being the increased efflux of antineoplastic drugs the main reason for this multidrug resistance, with a key role of the ABC superfamily. Likely, the interindividual variability in the pharmacological response among patients is well known, and may be due to intrinsically factors of the disease, genetic and environmental ones. Thus, the understanding of this variability, especially the genetic variability associated with the efficacy and toxicity of drugs, can provide a safer and more effective pharmacological treatment, so ABC genes are considered as important regulators due to their relationship with the reduction in pharmacological response. In this review, updated information about transporters belonging to this superfamily was collected, the possible role of these transporters in cancer, the role of genetic variability in their genes, as well as some therapeutic tools that have been tried to raise against main transporters associated with chemoresistance in cancer.
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