自噬
内质网
串扰
细胞器
线粒体
钙信号传导
细胞凋亡
化学
细胞生物学
生物
信号转导
生物化学
光学
物理
作者
Lucia Barazzuol,Flavia Giamogante,Tito Calì
出处
期刊:Cell Calcium
[Elsevier]
日期:2021-03-01
卷期号:94: 102343-102343
被引量:63
标识
DOI:10.1016/j.ceca.2020.102343
摘要
In the last decades, the communication between the Endoplasmic reticulum (ER) and mitochondria has obtained great attention: mitochondria-associated membranes (MAMs), which represent the contact sites between the two organelles, have indeed emerged as central hub involved in different fundamental cell processes, such as calcium signalling, apoptosis, autophagy and lipid biosynthesis. Consistently, dysregulation of ER-mitochondria crosstalk has been associated with different pathological conditions, ranging from diabetes to cancer and neurodegenerative diseases. In this review, we will try to summarize the current knowledge on MAMs’ structure and functions in health and their relevance for human diseases.
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