生物
核糖核酸
卵母细胞
爪蟾
细胞生物学
细胞质
亚细胞定位
RNA结合蛋白
长非编码RNA
计算生物学
电池极性
小RNA
基因
遗传学
胚胎
细胞
作者
Sarah E. Cabral,Kimberly L. Mowry
出处
期刊:Current Topics in Developmental Biology
日期:2020-01-01
卷期号:: 87-118
被引量:12
标识
DOI:10.1016/bs.ctdb.2020.02.007
摘要
RNA localization is a key biological strategy for organizing the cytoplasm and generating both cellular and developmental polarity. During RNA localization, RNAs are targeted asymmetrically to specific subcellular destinations, resulting in spatially and temporally restricted gene expression through local protein synthesis. First discovered in oocytes and embryos, RNA localization is now recognized as a significant regulatory strategy for diverse RNAs, both coding and non-coding, in a wide range of cell types. Yet, the highly polarized cytoplasm of the oocyte remains a leading model to understand not only the principles and mechanisms underlying RNA localization, but also links to the formation of biomolecular condensates through phase separation. Here, we discuss both RNA localization and biomolecular condensates in oocytes with a particular focus on the oocyte of the frog, Xenopus laevis.
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