纳米载体
药物输送
聚乙二醇
胶束
药理学
前药
两亲性
材料科学
PEG比率
毒品携带者
化学
生物材料
聚合物
纳米技术
药品
有机化学
医学
共聚物
财务
水溶液
经济
作者
Zhiping Zhang,Songwei Tan,Si‐Shen Feng
出处
期刊:Biomaterials
[Elsevier]
日期:2012-06-01
卷期号:33 (19): 4889-4906
被引量:493
标识
DOI:10.1016/j.biomaterials.2012.03.046
摘要
D-α-tocopheryl polyethylene glycol succinate (Vitamin E TPGS, or simply TPGS) is a water-soluble derivative of natural Vitamin E, which is formed by esterification of Vitamin E succinate with polyethylene glycol (PEG). As such, it has advantages of PEG and Vitamin E in application of various nanocarriers for drug delivery, including extending the half-life of the drug in plasma and enhancing the cellular uptake of the drug. TPGS has an amphiphilic structure of lipophilic alkyl tail and hydrophilic polar head with a hydrophile/lipophile balance (HLB) value of 13.2 and a relatively low critical micelle concentration (CMC) of 0.02% w/w, which make it to be an ideal molecular biomaterial in developing various drug delivery systems, including prodrugs, micelles, liposomes and nanoparticles, which would be able to realize sustained, controlled and targeted drug delivery as well as to overcome multidrug resistance (MDR) and to promote oral drug delivery as an inhibitor of P-glycoprotein (P-gp). In this review, we briefly discuss its physicochemical and pharmaceutical properties and its wide applications in composition of the various nanocarriers for drug delivery, which we call TPGS-based drug delivery systems.
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