化学
酰胺
冷凝
四氢呋喃
产量(工程)
咪唑
碳酸氢盐
有机化学
碳酸钾
水溶液
缩合反应
溶剂
催化作用
物理
热力学
材料科学
冶金
作者
Bryan Li,Charles K.‐F. Chiu,Richard F. Hank,Jerry A. Murry,Joshua A. Roth,Harry Tobiassen
摘要
The preparation of 2,4-disubstituted imidazoles from the condensation of α-haloketones with amidines is described. The optimal reaction protocol is to add the α-bromoketone solution to the amidine in aqueous tetrahydrofuran in the presence of potassium bicarbonate under vigorous reflux. Imidazole was isolated in 83−91% yield with >95% purity without column chromatography.
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