Efficient Method for the Synthesis of Optically Active 2‐Amino‐2‐chromene Derivatives via One‐Pot Tandem Reactions

Abstract The asymmetric synthesis of functionalized 2‐amino‐2‐chromene derivatives with high enantioselectivities via one‐pot tandem reactions of functionalized α,β‐unsaturated ketones with malononitrile catalyzed by 9‐amino‐9‐deoxyepiquinine ( 1a ) in combination with ( R )‐1,1′‐binaphth‐2,2′‐diyl hydrogen phosphate ( 1c ) is reported for the first time.