银屑病
生物
白细胞介素17
促炎细胞因子
白细胞介素23
免疫系统
免疫学
免疫
T细胞
谱系(遗传)
炎症
遗传学
基因
作者
M. Merle Elloso,Mireia Gómez‐Angelats,Anne M. Fourie
摘要
In recent years, the classic paradigm of Th1/Th2 CD4(+) T cell-mediated immunity has evolved to include the IL-17A-producing Th17 subset, a distinct proinflammatory CD4(+) T cell lineage. Accumulating evidence suggests that IL-17A and the Th17 pathway may play an important role in the pathology of psoriasis and in other immune-mediated inflammatory diseases. This review summarizes the preclinical and clinical evidence implicating Th17 cells in psoriasis and the therapeutic approaches, approved or under investigation, to target this pathway in psoriasis.
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