牛痘
病毒学
天花疫苗
天花
生物
狂犬病
正痘病毒
痘病毒科
狂犬病病毒
载体(分子生物学)
重组病毒
克隆(Java方法)
溶血酶
接种疫苗
弹状病毒科
重组DNA
基因
遗传学
作者
Paul-Pierre Pastoret,Alain Vanderplasschen
标识
DOI:10.1016/s0147-9571(03)00019-5
摘要
The discovery of Jenner in 1798 founded the science of immunology and eventually led to smallpox eradication from the earth in 1980 after a world-wide vaccination campaign with vaccinia virus (another poxvirus) and paradoxically, despite the eradication of smallpox, there has been an explosion of interest in vaccinia virus in the eighties. This interest has stemmed in part from the application of molecular genetics to clone and express foreign genes from recombinant vaccinia viruses. Vaccinia is also gaining renewed interest due to bioterrorism. These recombinant viruses have multiple applications in research and vaccinology and led to the development of vectored vaccines, such as the recombinant vaccinia rabies vaccine used to eliminate rabies in Western Europe and, more recently, in the United States. Secondly, alternative poxvirus vectors, such as avipox viruses, were proved to be even safer and efficacious non-replicating vectors (suiciole vectors) when used in non-avian species.
科研通智能强力驱动
Strongly Powered by AbleSci AI