Genetics of human superoxide dismutase

The formal genetics of superoxide dismutase has been studied in a family material from northern Sweden. The results verify the hypothesis that the three phenotypes SOD 1, SOD 2–1 and SOD 2 are controlled by two autosomal alleles. Although the SOD2 gene appears to be associated with somewhat lower enzyme activity, the SOD 2–1 and SOD 2 types were found not be associated with disease.