化学
对映体
色谱法
纤维素
洗脱
分析物
选择性
柱色谱法
分辨率(逻辑)
己烷
特里斯
有机化学
生物化学
人工智能
计算机科学
催化作用
作者
Cecilia Beatriz Marta Castells,Peter W. Carr
标识
DOI:10.1016/s0021-9673(00)00883-9
摘要
In this work, we study the influence of the mobile phase and column temperature on the enantioresolution of basic compounds on microparticulate porous zirconia coated with cellulose tris(3,5-dimethylphenylcarbamate) (CDMPC). The chiral analytes are amino compounds, including a number of beta-blockers. Analytes are eluted with hexane-alcohol mobile phases. We investigated the effect of alcohol (type and concentration), basic eluent additives, and column temperature on the parameters that control resolution (column efficiency, retention and selectivity). Conditions for achieving an adequate separation in the least time have been determined for numerous racemic mixtures. For most solutes, baseline resolution of the enantiomeric pair was achieved in less than 1 min; 12 of 13 pairs were separated in less than 2 min.
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